Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Here we demonstrate that the neurovasculature exhibits a unique transcriptional signature following inflammatory insults, and pharmacological inhibition of monoacylglycerol lipase using a newly characterized inhibitor, rescues the transcriptional profile of brain vasculature, and restores its functional homeostasis. RNAseq of neurovasculature isolated from mice treated with lipopolysaccharides or PBS in the presence and absence of an inhibitor of monoacylglycerol lipase