Shifts in Serum Bile Acid Profiles Associated with Barretts Esophagus and Stages of Progression to Esophageal Adenocarcinoma

Reflux bile acids are thought to promote EAC, but the role of systemic bile acids is unknown. This study aimed to assess associations between systemic bile acids and stages of Barretts esophagus progression. Subjects with and without BE were enrolled in this cross-sectional study. Targeted serum bile acid profiling was performed, and a subset of subjects completed a validated food frequency questionnaire. RNA sequencing was performed on BE or gastric cardia tissue to assess bile acid associations with gene expression.