Comparative Time Course Profiles of Phthalate Stereoisomers in Mice. Mus musculus

Analysis of gene expression level in a mouse tumorigenic phthalate, DEHP vs non-tumorigenic DNOP. The hypothesis tested in the present study was to identify early key event thresholds related to tumor outcomes in a two-year carcinogenicity bioassay. Our results highlight marked differences in the toxicity profiles of structurally similar phthalates and demonstrate quantitative relationships between early bioindicators and later tumor outcomes. Overall design: Total RNA obtained from liver samples subjected to 30wk exposures of cont, DEHP, DNOP. Samples processed with Illumina Mouse WG 8-v 2.0 beadarrays. Gene profiles generated for the compounds support observed key events in mode-of-action for these phthalates.