Dynamic Lineage Priming by ERK is Driven by Transcription Factor-Independent Enhancer Regulation [gene expression]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE131546
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资源简介：
Extensive analysis if the means by which ERK affects transcription via enhancer regulation in mouse embryonic stem cells. This study combines analysis of mRNA, and nascent RNA dynamics and correlates this with changes in transcription factor, co-factor, and RNAPII binding and activity. WT or KO ESCs were stimulated for 8hrs, or stimulated for 8hrs with 4OHT to activate the Raf-ErT2 fusion they express and then with a subesquent 2hr treatment with the Mek inbhibitor PD03
创建时间：
2019-11-11
