Development of a multi-layer degradable composite for stent application

Drug eluting bioresorbable stents treat narrowed arteries by keeping them open, release drug, degrade and adsorbed by body after fulfilling their function to avoid long-term medical complications. In this study, novel cytocompatible composites as 2D degradable stent models were developed, each consisting of a Mg alloy exhibiting strong tensile strength as a substrate, Poly(lactic-co-glycolic acid) polymer coating potentially serving a potential drug matrix role and supporting endothelial cell response as a top layer, and a silane polymer coating to reduce corrosion rate of Mg alloys and enhance cytocompatibility as an intermediate layer.