Genome-wide Analysis of Functional Sirtuin Chromatin Targets in Yeast

Sir2 and the homologous proteins, Hst1, Hst2, Hst3, and Hst4 from Saccharomyces cerevisiae are NAD+-dependent histone deacetylases of the sirtuin protein family沉默信息调节因子2（Sir2）及其酿酒酵母（Saccharomyces cerevisiae）来源的同源蛋白Hst1、Hst2、Hst3与Hst4，均为烟酰胺腺嘌呤二核苷酸（NAD+）依赖型组蛋白去乙酰化酶，隶属于沉默调节蛋白（sirtuin）蛋白家族。