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Photoactive Ru(II) Complexes With Dioxinophenanthroline Ligands Are Potent Cytotoxic Agents

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Figshare2016-02-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Photoactive_Ru_II_Complexes_With_Dioxinophenanthroline_Ligands_Are_Potent_Cytotoxic_Agents/2248993
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Two novel strained ruthenium­(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino­[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.
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2016-02-16
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