Wnt signaling pathway and pluripotency

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

本路径图源自多个资料来源，旨在为审视胚胎干细胞的多能性和自我更新过程中的Wnt信号传导及其相互作用组分提供一个理论框架。此路径图的核心组织主题包括已知促进自我更新或多能性的药物靶点（如BIO和IQ-1）以及核心多能性转录组分的上游调控因子（例如Nanog）。值得注意的是，目前尚不清楚所有描绘的组分是否均参与人类胚胎干细胞的该路径。对于大多数组分，均存在该路径的相互作用及客体/基因组的记录。