Aberrant lncRNA expression profiles in OSCC plasma. Homo sapiens

Carcinogenesis is a genetic process in which molecular changes occur earlier than histomorphological changes. The key to early detection of oral squamous cell carcinoma (OSCC) is to identify genetic alterations. However, aberrant lncRNA expression profiles in OSCC plasma is still largely unknown. Using an lncRNA microarray, we analyzed the aberrant lncRNA expression profiles in OSCC plasma compared with paired healthy volunteer plasma. Our data revealed 7473 differentially expressed (Fold Change >= 2.0, P-value <= 0.05) lncRNAs, among which 3972 lncRNAs were significantly up-regulated and 3501 lncRNAs were down-regulated in OSCC compared with paired healthy volunteer plasma. Overall design: Plasma was obtained from 3 healthy adult volunteers and 3 patients with OSCC. LncRNA expression profiles were evaluated by an Agilent Human LncRNA Array v4.0 (8 x 60K, Arraystar).