Adjusted HRR and 95% CI of Incident Acute Coronary Events Associated with the <i>COMT</i> Genotype^*, Plasma tHcy and Serum Folate and Gene-Homocysteine and Gene-Folate Interactions

Abbreviations: CI, confidence interval; COMT, catehol-O-methyltransferase; fol, serum folate concentration; HRR, hazard rate ratio; HRRi, hazard rate ratio for a multiplicative interaction; RERI, relative excess risk for interaction; tHcy, serum total homocysteine concentration. * COMT low activity Met158Met is ‘at-risk’ genotype for this study. The comparison group for the HRRs in the first three columns of the table is the same, i.e. subjects with lower plasma tHcy (<11.3 µmol/L) with COMT Met158Val or Val158Val genotype. †Model 1 is adjusted for age and examination years. ‡Model 2 is adjusted for age, examination years, serum HDL and LDL cholesterol and triglycerides, systolic blood pressure and smoking