IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
收藏reactome.org2025-03-26 收录
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Insulin receptor substrate 1 and 2 (IRS1, IRS2) bind to activated Interleukin-7 receptor complex . Interleukin-7 (IL7) stimulation of human thymocytes results in the rapid tyrosine phosphorylation of IRS1 and IRS2.
This is a black box event because the kinase responsible for IRS phosphorylation is unclear.
胰岛素受体底物1和2（IRS1、IRS2）与激活的IL-7受体复合物相结合。IL-7对人类胸腺细胞的刺激导致IRS1和IRS2的酪氨酸磷酸化迅速发生。这一过程为黑盒事件，因为负责IRS磷酸化的激酶尚不明确。
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