PRISM Repurposing 19Q4 Dataset

The PRISM Repurposing release contains small molecule viability datasets generated using the Broad Repurposing Library and the PRISM multiplexed cell-line viability assay.The primary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 4,518 compounds screened against 578 or 562 cell lines. The secondary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 1,448 compounds screened against 489 cell lines in an 8-step, 4-fold dilution, starting from 10uM. Technical redos for 147 previously screened oncology compounds have been added as of 11/22/2019. This data is identified using a `screen_id` of "MTS010". It is recommended to use MTS010 when available. MTS010 was not included in the analysis for Corsello et al. 2019, DOI:10.1101/730119.Data processing steps are described in the README files. Further descriptions of methods are available at https://doi.org/10.1101/730119.

PRISM复用发布版包含了利用Broad复用库和PRISM多路复用细胞系活力检测方法生成的的小分子活性数据集。主要PRISM复用数据集收录了对578或562个细胞系进行筛选的4,518个化合物的细胞系化学扰动活力筛选结果。次要PRISM复用数据集收录了对489个细胞系进行筛选的1,448个化合物的细胞系化学扰动活力筛选结果，该筛选过程采用8步、4倍稀释法，起始浓度为10uM。截至2019年11月22日，已将147个先前筛选的肿瘤学化合物技术重做结果添加其中。这些数据通过`screen_id`的“MTS010”进行标识。建议在可用时使用MTS010。在Corsello等人2019年的分析（DOI:10.1101/730119）中，MTS010并未包含。数据处理步骤已在README文件中描述。更多关于方法的描述可在https://doi.org/10.1101/730119找到。