five

Bone morphogenetic protein 7 promotes resistance to immunotherapy

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154993
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We previously generated a syngeneic preclinical model of NSCLC (p53R172HΔg/+KrasLA1/+) with acquired resistance to anti-PD1. In the current study, we investigated methylation differences in specific genomic regions comparing anti-PD1-resistant tumors (344SQR) with their parental-tumor counterparts (344SQP). DNA was isolated from 344SQP and 344SQR tumors treated with anti-PD1 for Reduced representation bisulfite sequencing (RRBS) analysis.
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2020-10-20
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