Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes
收藏Zenodo2025-06-23 更新2026-05-26 收录
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https://zenodo.org/doi/10.5281/zenodo.15722028
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资源简介：
metaCoNGA dataset
These data are part of the works published in the pre-print article metaCoNGA biorXiv
`cd4_top2000_hotspots_clustered.h5ad` and `cd8_top2000_hotspots_clustered.h5ad` are scanpy objects containing the clonotype-averaged expression for CD4+ and CD8+ subsets respectively. The 200 TCR autocorrelated genes described in the paper were used as features for dimensionality reduction.
`cd4_cdr3aa_biased_gex_nbrhoods_all_genes_reclustered.h5ad` and `cd8_cdr3aa_biased_gex_nbrhoods_all_genes_reclustered.h5ad` contain the subsets of CD4+ and CD8+ with pvalues below the selected threshold from the CDR3 amino acid enrichment analysis.
`tcr_clump_over10clones_full.tsv` is a table of all clonotypes within the 2173 TCR clumps with >10 clonotypes.
`tcr_clump_over10clones_big_clone_with_group_info.tsv` is a table showing a representative clonotype for each of the 2173 TCR clumps with >10 clonotypes with averaged gene expression for select genes and additional metadata.
提供机构：
Zenodo
创建时间：
2025-06-23
