Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099
收藏Protein Data Bank Japan2023-10-04 更新2026-03-21 收录
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Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099 Descriptor: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, SULFATE ION, ... Authors: Stams, T, Fodor, M. Deposit date: 2018-03-17 Release date: 2018-11-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
创建时间：
2018-03-17
