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Transgene-free generation of long-term hematopoietic stem cells

NIAID Data Ecosystem2026-05-02 收录

造血干细胞生成

生物力学刺激信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP301561 数据链接链接失效反馈

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资源简介：

Analyze the role of cyclic stretch and Yoda1-mediated Piezo1 activaiton in the endothelial-to-hematopoietic transition Overall design: Cyclic stretch and Yoda1-mediated Piezo1 activaiton

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创建时间：

2025-06-05

细胞重编程

造血干细胞生成

Patients with prolonged myelosuppression require frequent platelet and occasional granulocyte transfusions. Multi-donor transfusions induce alloimmunization, thereby increasing morbidity and mortality

NIAID Data Ecosystem60

Single cell profiling of hemogenic endothelium and its surrounding niche in the mouse dorsal aorta. Single cell profiling of hemogenic endothelium and its surrounding niche in the mouse dorsal aorta

造血干细胞生成

单细胞转录组学

The first hematopoietic stem cells originate from hemogenic endothelium (HE), that trans-differentiate into the lumen to form hematopoietic clusters. The molecular mechanisms driving this transition a

NIAID Data Ecosystem30

Single cell mRNA sequencing of de novo hematopoiesis from the fetal lung

造血干细胞生成

内皮-造血转化

Hemogenic endothelium, which gives rise to the earliest HSCs, is thought to be isolated to very early stages of development, peaking at E10.5 in mice. However, our data suggests there may be hemogenic

NIAID Data Ecosystem30

The hemogenic competence of endothelial progenitors is restricted by Runx1 silencing during embryonic development. Mus musculus

造血干细胞生成

发育基因调控

It has now been well established that hematopoietic stem and progenitor cells originate from a specialised subset of endothelium termed hemogenic endothelium (HE) via an endothelial-to-hematopoietic t

NIAID Data Ecosystem50

Transcriptome imposed by Notch ligands (Jag1 or Dll4) on ckit+ and ckit- cells from E11.5 AGM. Mus musculus

造血干细胞生成

Notch信号通路

Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This reg

NIAID Data Ecosystem30

Transgene-free generation of long-term hematopoietic stem cells

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