Summary of comparisons between the BRCA-like reference group and groups of patients who harbored a specific type of aberration in a candidate BRCA-like gene.

We evaluated whether somatic-mutation signatures from patients who harbored a given type of aberration (e.g., BARD1 germline mutation) were more similar to the BRCA-like reference group than expected by random chance. The numbers in this table represent empirical p-values from our resampling approach. In cases where no patient had a given type of aberration in a given gene, we list “N/A”. The “Any” group represents individuals who harbored any type of aberration in a given gene. We used Holm’s method to correct for testing multiple hypotheses.