HIV-RNA and CD4 values and estimated CD4 slope during elite control (EC), and throughout ART-naïve follow-up using the CASCADE dataset applied to 10 definitions of EC found in the literature.

Note- all values unless otherwise stated are median (IQR).†CD4 slope modelled on the square root scale with linear mixed models, specific p-values for CD4 slope and median number of CD4 measurements are presented in Table S1.‡CD4 slope highly significant pŦ Number of total CD4 and HIV-RNA measurements ŧ A: HIV-positive ≥6 months, with ≥2 consecutive HIV-RNA B: HIV- positive ≥1 year, with ≥1 HIV-RNA C: HIV- positive ≥1 year, with ≥1 HIV-RNA D: HIV- positive ≥1 year, with ≥3 HIV-RNA E: HIV- positive ≥1 year, with ≥3 consecutive HIV-RNA F: HIV- positive ≥1 year, with ≥3 consecutive HIV-RNA G:HIV- positive ≥2 years, with ≥2 HIV-RNA H: HIV- positive ≥5 years, with ≥5 consecutive HIV-RNA I: HIV- positive ≥10 years, with all measured HIV-RNA J: HIV-positive ≥10 years, with ≥90% of HIV-RNA (≥2 HIV-RNA ever)