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Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

ChEBI2023-05-22 更新2026-07-12 收录

合成致死筛选

肿瘤靶向治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-12939 数据链接链接失效反馈

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资源简介：

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

应用场景：

创建时间：

2023-05-22

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

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Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP抑制剂机制

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PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto

NIAID Data Ecosystem70

MYC-targeting by OMO-103 in solid tumours: a phase 1 trial

肿瘤靶向治疗

一期临床试验

A Phase I Dose-Escalation Study of a first-in-modality MYC inhibitor, OMO-103, in All-Comers Solid Tumors and identification of potential biomarkers

NIAID Data Ecosystem30

肿瘤靶分子临床研究信息数据集

肿瘤靶向治疗

临床研究

聚焦肿瘤靶分子临床研究全流程，整合靶点发现、临床试验设计、疗效数据、安全性评估等核心信息。数据经标准化清洗与专业校验，关联靶点分子结构、作用机制及临床结果，支持科研机构靶点验证、药企药物研发、临床机构方案优化，为靶分子临床转化提供高质量、可溯源的数据支撑。

江苏数据交易所80

Original images underlying Fig 3D.