Gene expression on 144 arrays representing 125 workers exposed to a range of benzene exposures. Homo sapiens

Human toxicogenomic studies to date have been of limited size, have mainly addressed exposures at the upper end of typical ranges of human exposure, and have often lacked precise, individual estimates of exposure. Previously, we identified genes associated with exposure to high (>10 ppm) levels of the leukemogen, benzene, through transcriptomic analyses of blood cells from small numbers of occupationally exposed workers. Here, we have expanded the study to 125 workers exposed to a wide range of benzene levels, including 10 ppm (Very High), and 42 unexposed controls (Control) who were frequency-matched to these subjects on the basis of age and gender were analyzed (technical replicates on some subjects, see SubjectID/description).