Inference of selective force on house mice genomes during secondary contact in East Asia

The house mouse (Mus musculus), commensal to humans, has spread globally via human activities, leading to secondary contact between genetically divergent subspecies. This pattern of genetic admixture can provide insights into the selective forces at play in this well-studied model organism. Our analysis of 163 house mouse genomes, mainly from East Asia, revealed substantial admixture between the subspecies castaneus and musculus, particularly in Japan and southern China. We revealed, despite the admixture, that all Y chromosomes in the East Asian samples belonged to the musculus-type haplogroup, potentially explained by genomic conflict under sex ratio distortion due to varying copy numbers of ampliconic genes on sex chromosomes. We also investigated the influence of natural selection on the post-hybridization of the subspecies castaneus and musculus in Japan. Even though the genetic background of most Japanese samples closely resembles the subspecies musculus, certain genomic regions o..., , , # Title of Dataset

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Inference of Selective Force on House Mice Genomes during Secondary Contact in East Asia

Analysis of 163 house mouse genomes, mainly from East Asia, revealed considerable admixture between the castaneus and musculus subspecies, especially in Japan and southern China. Despite the admixture, all Y chromosomes in the East Asian samples belonged to the musculus haplogroup, which could be explained by genomic alleles under sex ratio distortion due to different copy numbers of amplified genes on sex chromosomes.

This dataset contains configuration and script files for the simulation of X-chromosome, Y-chromosome, and mitochondrial genome introgression under sex ratio distortion, as well as for the demographic inference and admixture simulation of Mus musculus.

First Author Information
Name: Kazumichi Fujiwara
Institution: (1) Graduate School of Information Science and Technology, Hokkaido University/(2) Mouse Genomics Resource Laboratory, National Institute of Gene...