Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP
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Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP Descriptor: (2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-disulfanyloctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, O-[(1R,2R,3R)-5-{[(S)-{[(2R,3R,4R,5R)-2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydro furan-3-yl]oxy}(sulfanyl)phosphoryl]oxy}-1-(6-amino-9H-purin-9-yl)-1,2-dihydroxypentan-3-yl] dihydrogen (R)-phosphorothioate, Protein B2 Authors: Eaglesham, J.B, Kranzusch, P.J. Deposit date: 2018-08-02 Release date: 2019-02-06 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature, 566, 2019
创建时间：
2018-08-02
