Neural Pathways Modulation in the Anesthetized Rat Elicited by Trials of Transcranial Focused Ultrasound Stimulation

In these recordings, we recorded neuronal activities from cortical-thalamocortical (CTC) pathway, including the somatosensory cortex (S1) and posteromedial complex (POm) of the thalamus responded to different Pulse Repetition Frequencies (PRFs ) or Pulse Durations (PDs) and Pressure Levels of transcranial ultrasound focused stimulation (tFUS) using a 128-element transducer to stimulate either at S1or PoM. Recordings for S1 are taken using 64-channel Cambridge or Neuronexus electrodes and recordings for POm are taken using 32-channel Nueronexus electrodes. Ultrasound stimulation is delivered every 2.5 seconds and each recording has 500 trials. The Ultrasound Duration (UD) and pressure level used in each recording is 67ms. The PRFs, PDs and pressure levels for each recording can be found in the identifier field. For example, in BH596_3000_200_67_10, the PRF is 3000Hz, PD is 200us and pressure level is 10V. Detailed description about this dataset can be found in the following publication. Please cite the paper if you would use a portion of the dataset. Gao, H., Ramachandran, S., Yu, K., & He, B. (2025). Transcranial Focused Ultrasound Modulates Feedforward and Feedback Cortico-Thalamo-Cortical Pathways by Selectively Activating Excitatory Neurons. The Journal of Neuroscience, 45(23), e2218242025. https://doi.org/10.1523/JNEUROSCI.2218-24.2025