Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability [PacBio]

Our study uncovers a distinct biomarker for MSI that underlies the synthetic lethal dependence on WRN, thereby supporting the development of WRN-based therapeutics Overall design: Pacbio CLR was performed under different experimental condition in MSI and MSS cells to uncover expansions/deletions at TA dinucleontide repeats genome-wide