JMJD4 regulates PKM2 degradation of cardiomyocytes and is critical in the development of dilated cardiomyopathy

To investigate the role of Jmjd4 in dilated cardiomyopathy, we performed gene expression profiling with RNA-Seq results from heart samples of MCM+ Jmjd4f/f and control Jmjd4f/f mice, as well as neonatal rat ventricuar cardiomyocytes (NRVCs) treated with si-Jmjd4 and si-NC control.为探究Jmjd4在扩张型心肌病（dilated cardiomyopathy）中的作用，本研究通过RNA测序（RNA-Seq）对MCM+ Jmjd4f/f与对照Jmjd4f/f小鼠的心脏样本，以及经si-Jmjd4和si-NC对照处理的新生大鼠心室心肌细胞（neonatal rat ventricular cardiomyocytes, NRVCs）开展了基因表达谱分析。