Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling

A nickel-catalyzed,
enantioselective, three-component fluoroalkylarylation
of unactivated alkenes with aryl halides and perfluoroalkyl iodides
has been described. This cross-electrophile coupling protocol utilizes
a chiral nickel/BiOx system as well as a pendant chelating group to
facilitate the challenging three-component, asymmetric difunctionalization
of unactivated alkenes, providing direct access to valuable chiral
β-fluoroalkyl arylalkanes with high efficiency and excellent
enantioselectivity. The mild conditions allow for a broad substrate
scope as well as good functional group toleration.