DHCR24 attenuates doxorubicin-induced HUVECs senescence by inhibiting cell cycle arrest caused by DNA damage

Vascular endothelial cell senescence is closely linked to vascular aging and aging-related diseases, such as cardiovascular disease. DHCR24 catalyzes desmosterol's conversion to cholesterol and has been reported to inhibit oxidative stress and inflammation correlated with cellular senescence. However, the relationship between DHCR24 and cellular senescence remains unclear. Consequently, this study investigates the role of DHCR24 in doxorubicin-induced vascular endothelial cell senescence.