A Retinoic Acid-dependent Stroma-Leukemia Crosstalk Promotes Chronic Lymphocytic Leukemia Progression [microarray]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111470
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资源简介：
In B-cell chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival and expansion. Using the Eμ-TCL1 mouse model, we demonstrate that leukemic cells induce the activation of retinoid acid synthesis and signaling in stromal cells of the lymphoid microenvironment. Four stromal samples cocultured with Eμ-TCL1 leukemic cells and four stromal samples cocultured with control (splenic) B cells
创建时间：
2018-06-14
