Mettl3-dependent m6A modification in postnatal liver
收藏NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE197799
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资源简介：
Liver-specific deficiency of Mettl3 causes liver injury. By performing RNA sequencing (RNA-seq) analysis on the Mettl3-deficient versus control livers, we identified the potential target genes that were closely associated with the liver phenotype in liver-specific Mettl3 knockout mice. RNA-seq analysis revealed extensive metabolic reprogramming in Mettl3-deficient livers. These results demonstrated that Mettl3 coordinates metabolic homeostasis and functional maturation during postnatal liver development. mRNA was isolated and subject to m6A RNA immunoprecipitation, fractioning each mRNA pool into input, anti-m6A-antibody-tagged samples. Libraries were prepared and sequenced from each fraction, with 3 biological replicates per fraction per wild-type or Mettl3-deficient mice.
创建时间：
2022-06-09
