Naa10p Inhibits Beige Adipocyte-mediated Thermogenesis through N-alpha-acetylation of Pgc1-alpha
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133726
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资源简介：
We report that both conventional and adipose-specific Naa10p deletions in mice result in increased energy expenditure, thermogenesis, beige adipocyte differentiation and activation. Mechanistically, Naa10p acetylates the N-terminus of Pgc1-alpha and prevents it from interacting with Ppar[gamma] to activate key genes, such as Ucp1, involved in beige adipocyte function. mRNA profiles of 2 biological replicates of each group with or without beige adipocyte induction for 2 and 6 days
创建时间：
2019-11-14
