Gene sets that are differentially expressed (T-ALL versus Healthy) using Gene Expression Omnibus Accession GSE13204 using a False Discovery Rate of 1 × 10−70.

Individual genes within each set can be found at software.broadinstitute.org/gsea/msigdb [2]. Individual gene p-values are computed with the t-test. Description of gene sets in Table 8 from Subramanian et al. [2]. 1. “Genes down-regulated in response to ultraviolet (UV) radiation” 2. “Genes involved in Signalling by NGF” 3. “Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins.” 4. “Genes down-regulated by KRAS activation” 5. “Regulation of actin cytoskeleton” 6. “Genes up-regulated in response to low oxygen levels (hypoxia)” 7.“Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior.” 8.“Genes encoding components of apical junction complex”.