Single cell RNA-seq from Trim28 ovary knockout and wildtype mice ovaries and testis

Single cell RNA-seq (scRNA-seq) from Trim28 ovary knockout and wildtype mice ovaries and testis to help elucidate the function of Trim28 in the adult mouse ovaries. The analysis revealed that loss of Trim28 in the adult mouse ovaries lead to a transcriptional reprogramming of the Granulosa cells towards the Sertoli cell fate. Therefore, Trim28 has a function to maintain the adult ovarian cell identity 10X scRNA-seq from Trim KO 8 week mouse ovaries, wildtype 8 week mice ovaries and testis本数据集源自Trim28卵巢敲除型与野生型小鼠的卵巢、睾丸组织的单细胞RNA测序（scRNA-seq），旨在阐明Trim28在成年小鼠卵巢中的功能。分析结果显示，成年小鼠卵巢中Trim28的缺失会导致颗粒细胞向支持细胞（Sertoli cell）命运发生转录重编程。据此可知，Trim28具备维持成年卵巢细胞身份的功能。本数据集包含8周龄Trim28敲除小鼠卵巢、8周龄野生型小鼠卵巢及睾丸的10X scRNA-seq数据。