Figure 6

Figure 6b: [K+]RE and pH values of recycling endosomes (REs) in WT cells. Figure 6c: [K+]RE and pH values of REs in WT cells treated with tetraethyl ammonium chloride (TEA) Figure 6d: [K+]RE and pH values of REs in UT cells treated with TEA. Figure 6e: [K+]RE and pH values of REs in WT cells treated with cisapride. Figure 6f: [K+]RE and pH values of REs in G601S cells. Figure 6g: [K+]RE and pH values of REs in G601S cells treated with dofetilide overnight and after wash out. Figure 6i: I-V curves recorded from WT cells and G601S cells in standard extracellular saline. Figure 6j: I-V curves recorded from WT cells and G601S cells in modified extracellular saline mimicking ion gradients across RE membranes. Figure 6k: Plot of peak IKv11.1 refcorded from WT cells and G601S cells in standard extracellular saline. Figure 6l: Plot of peak IKv11.1 recorded from WT cells and G601S cells in modified extracellular saline mimicking ion gradients across RE membranes.