G. lamblia PIP-binding proteins.

A compilation of all PIP-binding domains identified in the Giardia Genome Database (www.giardiadb.org; GDB) using previously characterized domains [24] as baits for HMM-based homology searches (column 1). Predicted giardial orthologs are present for PIP-binding domains ENTH, PH, FYVE, PX, BAR, FERM and PROPPINs (column 2) and mostly retrieve the correct domains when used as baits for reverse HHpred searches (column 4). Except for Glepsin, GlPXD2 and GlPROP1 and 2, all others are currently annotated on GDB as generically “hypothetical”, i.e. of unknown function (column 6). Each orthologue was assigned a name used throughout this report (column 7). Functional domain predictions using SMART (http://smart.embl-heidelberg.de/; column 8) and subcellular localization data (column 9) either previously reported or acquired in this study (column 10), are also included.