Demographic and trial participation trajectory of parents participating in RECRUIT by individual trial and breakdown of practitioners by individual trial.

17 of the 8 families who declined MENDS, did so before attending a clinic appointment and as such there are no recorded trial discussions for them. In these instances, parents were interviewed about their discussions with community paediatricians, telephone conversations with the research nurse and their views on the trial and the PIL.2TIPIT is a neonatal trial; hence the median age is 0.3Higher scores indicate greater deprivation.4Mean and standard deviation exclude 3 families from Northern Ireland.5Five doctors were also interviewed who regularly recruited to trials but were not recruiting to the four participating trials.