ProteinExplorer

it has remained challenging to find and inspect spectra of peptides covering functional protein regions or matching novel proteins. ProteinExplorer addresses these challenges with an intuitive interface mapping tens of millions of identifications to functional sites on nearly all human proteins. Additionally, ProteinExplorer facilitates the selection and inspection of HPP-compliant peptides whose spectra can be matched to spectra of synthetic peptides and already includes HPP-compliant evidence for 107 missing (PE2, PE3, and PE4) and 23 dubious (PE5) proteins.寻找并检视覆盖蛋白质功能区域或匹配新型蛋白质的肽段质谱图谱，长期以来始终是一项颇具挑战性的任务。ProteinExplorer通过直观的交互界面，将数千万条蛋白质鉴定结果映射至几乎所有人类蛋白质的功能位点上，有效解决了上述难题。此外，该工具支持筛选与检视符合HPP标准的肽段，此类肽段的质谱图谱可与合成肽段的质谱图谱实现匹配；目前其已为107个PE2、PE3及PE4级缺失蛋白质与23个PE5级可疑蛋白质提供符合HPP标准的佐证证据。

搜集汇总

背景与挑战

背景概述

ProteinExplorer是一个用于人类蛋白质组探索的数据集，它通过直观界面将数千万个肽鉴定结果映射到蛋白质功能位点，解决了查找和检查功能区域或新蛋白质肽谱的挑战。该数据集支持浏览和筛选蛋白质，并包含符合HPP标准的肽证据，已涵盖多个缺失和可疑蛋白质的验证信息。