FASLG

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

本基因属于肿瘤坏死因子超家族。编码的跨膜蛋白的主要功能是通过与FAS结合诱导细胞凋亡。FAS/FASLG信号通路对于免疫系统调节至关重要，包括T细胞的活化诱导性细胞死亡（AICD）和细胞毒性T淋巴细胞诱导的细胞死亡。此外，该通路亦与多种癌症的进展相关。已有报道指出，本基因的缺陷可能与某些系统性红斑狼疮（SLE）病例有关。此外，还存在可变剪接的转录变体。[由RefSeq提供，2014年11月]