Transcriptomic and epigenetic changes during mouse brain aging

Aging represents a major risk for human neurodegenerative disorders, such as dementia and Alzheimer disease, and is associated with a functional decline in neurons and impaired synaptic plasticity, leading hence to a gradual decline in memory. Therefore, understanding how aging-associated changes in the brain occur has been important in the field of neuroscience and medical sciences. Previous research has identified molecular and functional changes associated with brain aging through histological and physiological studies. Here, we try to elucidate the role of transcriptomic and epigenetic changes in the alteration of brain function during aging.