Research on the mechanism of ketogenic diet in radiotherapy of tumors

Ketogenic diet, a unique dietary pattern characterized by high fat and low carbohydrate intake, effectively restricts the energy supply to tumor cells through metabolic reprogramming, thereby exerting a significant impact on tumor initiation and progression. This paper aims to review the application of ketogenic diet in the field of radiation therapy for cancer, and delve into the potential mechanisms by which the combination of ketogenic diet and radiation therapy enhances anti-tumor efficacy, based on the core “4R” principles of radiobiology (repair, repopulation, reoxygenation, and redistribution). The objective is to uncover the unique value of this combined approach in cancer treatment and to provide a foundational research reference for dietary interventions for cancer patients undergoing radiation therapy, ultimately advancing research progress and clinical application in this domain.