Multimodal spatial profiling of colorectal cancer using Orion

The collection comprises preservation-quality files of Minerva output files without needing download terabyte scale images. To view data in a browser follow this link: https://tissue-atlas.org/orion-crc-1 This dataset uses the Minerva Suite, a series of software tools developed by the Laboratory of Systems Pharmacology to visualize multiplexed tissue image data in a web browser. Researchers or pathologists can annotate and describe images for users and users can use zooming and panning features to explore the full resolution images without needing to download multi-GB/TB image files. These annotated and unannotated images are created by uploading quality controlled ome.tiffs and segmentation masks, along with channel metadata and text descriptions, into the Minerva Author tool. These input files produce .json files, an .html file, and hundreds of .jpg pyramid files that make the images browsable online.本数据集包含具备保存级质量的Minerva输出文件，无需下载TB级体量的图像文件。若需在浏览器中查看数据，请访问以下链接：https://tissue-atlas.org/orion-crc-1。本数据集采用Minerva Suite——由系统药理学实验室（Laboratory of Systems Pharmacology）开发的一系列软件工具，用于在网页浏览器中可视化多重组织成像数据。研究人员或病理学家可对图像进行标注并撰写说明以供用户查阅，用户则可通过缩放与平移功能浏览全分辨率图像，无需下载多GB乃至TB级的图像文件。上述带标注与无标注的图像，是通过将经过质量管控的ome.tiffs文件、分割掩码（segmentation masks），连同通道元数据与文本说明上传至Minerva Author工具生成的。此类输入文件将生成.json文件、.html文件以及数百个.jpg金字塔文件，从而实现图像的在线浏览。