Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
收藏PubMed Central1996-09-17 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38386/
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资源简介：
NF-kappa B/Rel transcription factors are central regulators of mammalian immunity and are also implicated in the induction of cecropins and other antibacterial peptides in insects. We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an I kappa B-like domain. Relish is strongly induced in infected flies, and it can activate transcription from the Cecropin A1 promoter. A Relish transcript is also detected in early embryos, suggesting that it acts in both immunity and embryogenesis. The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-09-17
