Sakmann2000_SodiumCurrent_ModelA

This a model from the article:
Distribution of a persistent sodium current across the ventricular wall in
guinea pigs.

Sakmann BF, Spindler AJ, Bryant SM, Linz KW, Noble D. Circ Res
2000 Nov 10;87(10):910-4 11073887
,
Abstract:

A tetrodotoxin-sensitive persistent sodium current, I(pNa), was found in guinea
pig ventricular myocytes by whole-cell patch clamping. This current was
characterized in cells derived from the basal left ventricular subendocardium,
midmyocardium, and subepicardium. Midmyocardial cells show a statistically
significant (P<0.05) smaller I(pNa) than subendocardial and subepicardial
myocytes. There was no significant difference in I(pNa) current density between
subepicardial and subendocardial cells. Computer modeling studies support a role
of this current in the dispersion of action potential duration across the
ventricular wall.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Sakmann BF, Spindler AJ, Bryant SM, Linz KW, Noble D. (2000) - version=1.0

The original CellML model was created by:
Penny Noble

[e-mail]
The University of Oxford
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