Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides

On the basis of mechanism-driven
reaction design, a Pd-catalyzed
nucleophilic fluorination of aryl bromides and iodides has been developed.
The method exhibits a broad substrate scope, especially with respect
to nitrogen-containing heteroaryl bromides, and proceeds with minimal
formation of the corresponding reduction products. A facilitated ligand
modification process was shown to be critical to the success of the
reaction.