Network Toxicology and Multi-omics Analysis

NIAID Data Ecosystem2026-05-10 收录

网络毒理学

肾病分子机制

数据链接：

https://figshare.com/articles/dataset/Network_Toxicology_and_Multi-omics_Analysis/30900119 数据链接链接失效反馈

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资源简介：

The original data code for the article "Revealing the Molecular Toxicity of Microplastics in Diabetic Nephropathy: Integrated Insights from Network Toxicology and Multi-omics Analysis."

创建时间：

2025-12-17

Profile of podocyte translatome during development of type 2 and type 1 diabetic nephropathy using podocyte-specific TRAP mRNA RNA-seq. Profile of podocyte translatome during development of type 2 and type 1 diabetic nephropathy using podocyte-specific TRAP mRNA RNA-seq

肾病分子机制

细胞翻译组学

We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence fro

NIAID Data Ecosystem70

STING-dependent inflammation and redox homeostasis maintained by ACSL4 in renal epithelial cells promotes hypertension-associated chronic kidney disease. STING-dependent inflammation and redox homeostasis maintained by ACSL4 in renal epithelial cells promotes hypertension-associated chronic kidney disease

肾病分子机制

基因表达谱分析

To determine the function of STING in kidney epithelial cells, we constructed conditional STING knockout mice (CDH16KO mice).We then performed gene expression profiling analysis using data obtained fr

NIAID Data Ecosystem20

DataSheet4_Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling.zip

肾病分子机制

足细胞焦亡信号通路

Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in diabetic kidney disease (

NIAID Data Ecosystem10

Data_Sheet_5_HIF-1α Alleviates High-Glucose-Induced Renal Tubular Cell Injury by Promoting Parkin/PINK1-Mediated Mitophagy.ZIP

肾病分子机制

细胞自噬通路

It is well-established that mitophagy leads to Diabetic Nephropathy (DN) and renal failure. Mitophagy mediated by a Hypoxia-inducible factor-1α (HIF-1α) plays a beneficial role in many diseases. Never

NIAID Data Ecosystem20

Identification of novel pathogenic mutations in ATP6V0A4 associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease

肾小管酸中毒遗传学

肾病分子机制

Distal renal tubular acidosis (dRTA) is a rare renal disorder caused by genetic mutations or secondary factors. If untreated, it can result in a significant electrolyte imbalance and progressive chron

DataCite Commons2025-08-08 更新10

Network Toxicology and Multi-omics Analysis

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