Comparison of the head, rod and tail domain sequences of GFAP isoforms across species.

For each species, the exon usage for isoforms with 3′end splice variation is shown, relative to the major isoform GFAPα. For each isoform, the total length of the polypeptide is shown in terms of number of aa, followed by the length of the combined head+rod domains in brackets (i.e encoded by exons 1–6, see Figure 1B). The tail domain consists of exons 7–9 in GFAPα, exons 7 and 7a in GFAPδ/ε and exon 7b (which includes exon 7, intron 7a and exon 7a, see Figure 1B, [36]) in GFAPκ. The length of the complete tail domain is shown for each isoform and the length of the variable regions for GFAPδ/ε and GFAPκ in brackets. The above data were generated from the UniProt Knowledgebase database.