Revisiting Amyloid Peptide Oligomers in Alzheimer's Disease Pathogenesis: microXRF mapping of neuronal cells

Alzheimer’s Disease (AD) research is a global priority, focusing on understanding its key drivers to improve diagnosis, prevention, and treatment. Neurons, with high energy demands and low glycolysis rates, rely heavily on oxidative phosphorylation (OXPHOS). Mitochondrial dysfunction, a factor in AD, disproportionately impacts neurons. A hallmark of AD is amyloid aggregates, primarily A(1-40) and A(1-42) peptides derived from amyloid precursor protein (APP). Recent research highlights intracellular A (iA) accumulation in neurons during early disease stages. Preliminary studies show that soluble iA oligomers drive mitochondrial OXPHOS hyperactivity, potentially causing oxidative stress