Temporally-resolved proteomic profiling of mouse pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive matrix deposition and fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrix proteome (matrisome) of the highly-metastatic KPC and poorly-metastatic KPflC mouse models of pancreatic cancer using data independent acquisition (DIA) mass spectrometry proteomics.