Scale drop disease virus (SDDV) and Lates calcarifer herpes virus (LCHV) co-infection downregulate immune relevant pathways and cause splenic and kidney necrosis in barramundi under commercial farming conditions

Marine farming of barramundi in Southeast Asia is currently severely affected by viral diseases. To better understand the biological implications and gene expression response of barramundi in commercial farming conditions during a disease outbreak, the presence of pathogens, comparative RNAseq and histopathology targeting multiple organs of clinically sick and healthy juveniles were investigated.