Mammary fat pad and intraductal xenografts with both DCIS.COM-lacZ and DCIS.COM-SOX11 cell lines to characterize the changes in mRNA expression in invasive cancers.. Gene expression in DCIS.COM-lacZ and DCIS.COM-SOX11 xenografts

DCIS.COM-lacZ and DCIS.COM-SOX11 were injected intraductally into the mammary fat pad as nine replicates. At 6 week and 12 weeks post-injection, the mammary glands were collected. Similarly, DCIS.COM-lacZ and DCIS.COM-SOX11 were injected orthotopically into the mammary fat pad as five replicates. At 6 weeks post-injection, the mammary glands were collected. RNA-sequencing was utilised to analyse gene expression profiles from RNA isolated from these cells.