Identification of the targets of the oxidative response repressor SisPerR in Saccharolobus islandicus REY15A. Identification of the targets of the oxidative response repressor SisPerR in Saccharolobus islandicus REY15A

In our current study, SisPerR was revealed as a transcriptional repressor in response to oxidative stress in Saccharolobus islandicus REY15A. Deletion of sisperR abolishes the oxidative stress-induced expression of a large number of genes. To identify the target genes directly bound by SisPerR in vivo, chromatin immunoprecipitation-sequencing (ChIP-seq) was performed. Overall design: Chromatin immunoprecipitation-sequencing (ChIP-seq) for SisPerR was performed using anti-SisPerR antibody in Saccharolobus islandicus REY15A.